2. Membrane Transporter/Ion Channel
  3. CFTR
  4. K41498 TFA

K41498 TFA is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. K41498 TFA is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 TFA can be used for hypotension study.

For research use only. We do not sell to patients.

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K41498 TFA Chemical Structure

K41498 TFA Chemical Structure

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5 mg USD 220 In-stock
10 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of K41498 TFA:

K41498 TFA Related Antibodies

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Description

K41498 TFA is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. K41498 TFA is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 TFA can be used for hypotension study[1].

Molecular Weight

3632.20 (free base)

Formula

C162H276N48O46.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

{D-Phe}-His-Leu-Leu-Arg-Lys-{Nle}-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2
Sequence Shortening

{D-Phe}-HLLRK-{Nle}-IEIEKQEKEKQQAANNRLLLDTI-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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K41498 TFA Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K41498K 41498K-41498CFTRCystic fibrosis transmembrane conductance regulatorCRF2 receptorhypotensionInhibitorinhibitorinhibit

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