Kaolin 

Kaolin is a family of kaolinitic clays, which is found in the earth's crust. Kaolin alleviates the toxicity of graphene oxide for mammalian cells. Kaolin can be utilized in industrial, cosmetic and medical fields, excipient^{[1][2][3][4][5]}.

Kaolin (50, 100 μg/mL, 72 h) combined with graphene oxide (50, 100 μg/mL, 72 h) reduces the toxicity of graphene and decreases the percentage of cells in HCT-116 cells^[3].
Kaolin (100 μg/mL, 30-180 min) induces intercellular ROS generation in RAW264 cells^[4].
Kaolin (100 μg/mL, 24 h) increases the concentrations of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in RAW264 cells^[4].
Kaolin (100 μg/mL, 60 min) increases DNA damage in the A549 cells co-cultured with RAW264 cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kaolin (0.05 and 0.2 mg, intratracheal instillation, lasting for 3 h and 24 h) induces DNA damage in the lungs of mice^[4].
Kaolin (5.0/0.1 mg/mL in 0.15 M NaCl, intratracheal inoculation, lasting for 24 h-210 days) incites acute inflammatory reaction at early periods and increases in the fibroblastic activity in the focal areas in mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

258.16

1332-58-7

Solid

White to off-white

[Kaolin]

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  [Content Brief]

  [2]. Zhang Z H, et al. Geopolymer from kaolin in China: An overview[J]. Applied Clay Science, 2016, 119: 31-41.

  [3]. Rozhina E, et al. Kaolin alleviates the toxicity of graphene oxide for mammalian cells. Medchemcomm. 2019 Jun 10;10(8):1457-1464.  [Content Brief]

  [4]. Kato T, et al. Effect of physicochemical character differences on the genotoxic potency of kaolin. Genes Environ. 2017 May 1;39:12.  [Content Brief]

  [5]. Sahu AP, Shanker R, Zaidi SH. Pulmonary response to kaolin, mica and talc in mice. Exp Pathol (Jena). 1978;16(1-6):276-82.  [Content Brief]