Kievitone

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Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity.

For research use only. We do not sell to patients.

Kievitone Chemical Structure

CAS No. : 40105-60-0

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Description

Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity^[1]^[2].

In Vitro

Kievitone (0-40 μM; 4 days) inhibits the proliferation of the oestrogen receptor (ER)-positive breast cancer cell lines MCF-7 and T47D and the ER-negative breast cancer cell line SKBR3 (IC₅₀ values 5-18 μM)^[2].
Kievitone (0-40 μM; 48 h) inhibits DNA synthesis of MCF-7 cells stimicrolated by insulin-like growth factor 1, insulin-like growth factor 2, basic fibroblast growth factor or transforming growth factor α^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	MCF-7, T47D and SKBR3 cells
Concentration:	0-40 μM
Incubation Time:	4 days
Result:	Inhibited breast cancer cell proliferation in a dose-dependent manner.

Molecular Weight

356.37

Formula

C₂₀H₂₀O₆

CAS No.

40105-60-0

SMILES

O=C1C(COC2=C(C(O)=CC(O)=C12)C/C=C(C)\C)C3=CC=C(C=C3O)O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Smith DA, et, al. Kievitone: the principal antifungal component of “substance II” isolated from Rhizoctonia-infected bean tissues. 1973 Apr;3(14):179-84.

[2]. Hoffman R. Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein. Biochem Biophys Res Commun. 1995 Jun 15;211(2):600-6. [Content Brief]

Kievitone Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kievitone40105-60-0FungalIsoflavanonePhaseolus vulgaris L.Rhizoctonia solani KühnMCF-7T47DSKBR3antifungalInhibitorinhibitorinhibit

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