2. GPCR/G Protein Neuronal Signaling
  3. GPR55
  4. KLS-13019

KLS-13019 is an orally active GPR55 receptor antagonist and a structural analogue of cannabidiol (CBD). It can prevent and reverse chemotherapy-induced peripheral neuropathy (CIPN) in a dose-dependent manner in rats.

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KLS-13019 Chemical Structure

KLS-13019 Chemical Structure

CAS No. : 1801243-39-9

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KLS-13019 Related Antibodies

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Description

KLS-13019 is an orally active GPR55 receptor antagonist and a structural analogue of cannabidiol (CBD). It can prevent and reverse chemotherapy-induced peripheral neuropathy (CIPN) in a dose-dependent manner in rats[1].

Cellular Effect
Cell Line Type Value Description References
Hippocampal neurone EC50
0.04 μM
Compound: 16; KLS-13019
Neuroprotective activity in rat hippocampal neurons assessed as protection against ammonium acetate induced cell death by measuring neuronal viability after 5 hrs by carboxyfluorescein diacetate dye based fluorimetric analysis
Neuroprotective activity in rat hippocampal neurons assessed as protection against ammonium acetate induced cell death by measuring neuronal viability after 5 hrs by carboxyfluorescein diacetate dye based fluorimetric analysis
[PMID: 27096053]
Hippocampal neurone EC50
0.04 μM
Compound: 16; KLS-13019
Neuroprotective activity in rat hippocampal neurons assessed as protection against ammonium acetate induced cell death after 5 hrs by propidium iodide staining based fluorimetric analysis
Neuroprotective activity in rat hippocampal neurons assessed as protection against ammonium acetate induced cell death after 5 hrs by propidium iodide staining based fluorimetric analysis
[PMID: 27096053]
Hippocampal neurone EC50
0.05 μM
Compound: 16; KLS-13019
Neuroprotective activity in rat hippocampal neurons assessed as protection against ethanol induced cell death after 5 hrs by propidium iodide staining based fluorimetric analysis
Neuroprotective activity in rat hippocampal neurons assessed as protection against ethanol induced cell death after 5 hrs by propidium iodide staining based fluorimetric analysis
[PMID: 27096053]
Hippocampal neurone EC50
0.08 μM
Compound: 16; KLS-13019
Neuroprotective activity in rat hippocampal neurons assessed as protection against ethanol induced cell death by measuring neuronal viability after 5 hrs by carboxyfluorescein diacetate dye based fluorimetric analysis
Neuroprotective activity in rat hippocampal neurons assessed as protection against ethanol induced cell death by measuring neuronal viability after 5 hrs by carboxyfluorescein diacetate dye based fluorimetric analysis
[PMID: 27096053]
Molecular Weight

355.47

Formula

C22H29NO3
CAS No.
SMILES

CC([C@@H]1CCC(C)=C[C@H]1C2=C(C=C(C=C2O)CC3CN(C3)C(C)=O)O)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KLS-13019 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KLS-130191801243-39-9KLS13019KLS 13019GPR55G protein-coupled receptor 55Chemotherapy-induced peripheral neuropathyInhibitorinhibitorinhibit

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HY-123239
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