Kolavenic acid analog (Synonyms: KAA)

Cat. No.: HY-146146: FAQs
Data Sheet Handling Instructions

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Kolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes.

For research use only. We do not sell to patients.

Kolavenic acid analog Chemical Structure

CAS No. : 2379777-37-2

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	81.9 μM Compound: 2; KAA	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 31753800]
WI-38	IC₅₀	100 μM Compound: 2; KAA	Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 31753800]

Molecular Weight

402.57

Formula

C₂₅H₃₈O₄

CAS No.

2379777-37-2

SMILES

O=C(O)/C=C(C)/CC[C@]1(C)[C@H](C)C[C@@H](OC(/C(C)=C/C)=O)[C@@]2(C)C(C)=CCC[C@@]12[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kurisawa N, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020 Jan 1;28(1):115154. [Content Brief]

Kolavenic acid analog Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kolavenic acid2379777-37-2KAAKinesinHSET/KIFC1MDA-MB-231anticancerInhibitorinhibitorinhibit

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