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  4. Koshidacin B

Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.

For research use only. We do not sell to patients.

Koshidacin B Chemical Structure

Koshidacin B Chemical Structure

CAS No. : 2925302-01-6

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Koshidacin B Related Antibodies

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Description

Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection[1].

IC50 & Target

IC50: 0.89 μM (P. falciparum FCR3 strain), 0.83 μM (P. falciparum K1 strain), 14.7 μM (human MRC-5 cells)[1]
Cellular Effect
Cell Line Type Value Description References
MRC5 CC50
14.7 μM
Compound: 2
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 36282784]
In Vitro

Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC50 values of 0.89 and 0.83 μM, respectively[1].
Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC50 value of 14.7 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Koshidacin B Related Antibodies
In Vivo

Koshidacin B (30 mg/kg; i.p.; once daily for 4 d) shows vivo antiplasmodial effects[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. berghei N strain-infected ICR (CD1) mice[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
Result: Suppressed 41% of malaria parasites.
Molecular Weight

544.64

Formula

C28H40N4O7
CAS No.
SMILES

OC[C@H](O)C(CCCCC[C@H](NC([C@H]1CCCN1C([C@@H](NC(C(C)(C)N2)=O)CC3=CC=CC=C3)=O)=O)C2=O)=O
Structure Classification
Initial Source

Pochonia boninensis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Koshidacin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Koshidacin B2925302-01-6Parasitecyclic tetrapeptideFCR3K1antiplasmodialMRC-5CD1malaria parasiteInhibitorinhibitorinhibit

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