2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D inhibitor 20

KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor. KRAS G12D inhibitor 20 has antitumor activity.

For research use only. We do not sell to patients.

KRAS G12D inhibitor 20 Chemical Structure

KRAS G12D inhibitor 20 Chemical Structure

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KRAS G12D inhibitor 20 Related Antibodies

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Description

KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor. KRAS G12D inhibitor 20 has antitumor activity[1].

IC50 & Target[1]

KRas G12D

 

In Vitro

KRAS G12D inhibitor 20 (72 h) shows antiproliferative activity against PANC-1 (KRAS G12D) and BxPC3 (KRASwt) human pancreatic cancer cell lines, with IC50s of 5.5 and 8.2 μM, and is low toxic for normal cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS G12D inhibitor 20 Related Antibodies
In Vivo

KRAS G12D inhibitor 20 (6 mg/kg, i.p., 6 injections) has no significant change in body weight in healthy BALB/c female mice[1].
KRAS G12D inhibitor 20 (6 mg/kg, i.p.) reduces tumor volume by 13.1% in xenograft mouse models using immunodeficient SCID male mice bearing KRASG12D (PANC-1)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

342.44

Formula

C18H26N6O
SMILES

O=C(NCCCC1N(C=CC=C2)C2N=N1)C3=NNC4CCCCCC43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRAS G12D inhibitor 20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12D inhibitor 20RasPANC-1BxPC3pancreatic cancerInhibitorinhibitorinhibit

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KRAS G12D inhibitor 20
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