2. GPCR/G Protein MAPK/ERK Pathway Stem Cell/Wnt
  3. Ras ERK p38 MAPK
  4. KRAS inhibitor-27

KRAS inhibitor-27 (Compound 15h) is the inhibitor for KRAS. KRAS inhibitor-27 inhibits KRAS G12D/G12V mutated cells AsPC-1, SW620 and KRAS wildtype cell HT-29 with IC50 of 378, 0.6 and 3230 nM, respectively. KRAS inhibitor-27 inhibits ERK phosphorylation (IC50 in cell AsPC-1 and SW620 is 0.6 nM and 1 nM), reduces the expression of DUSP4, thereby inhibiting MAPK signaling pathway.

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KRAS inhibitor-27 Chemical Structure

KRAS inhibitor-27 Chemical Structure

CAS No. : 3033690-83-1

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KRAS inhibitor-27 Related Antibodies

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K-Ras H-Ras N-Ras Ras

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

KRAS inhibitor-27 (Compound 15h) is the inhibitor for KRAS. KRAS inhibitor-27 inhibits KRAS G12D/G12V mutated cells AsPC-1, SW620 and KRAS wildtype cell HT-29 with IC50 of 378, 0.6 and 3230 nM, respectively. KRAS inhibitor-27 inhibits ERK phosphorylation (IC50 in cell AsPC-1 and SW620 is 0.6 nM and 1 nM), reduces the expression of DUSP4, thereby inhibiting MAPK signaling pathway[1].

Molecular Weight

657.11

Formula

C31H28ClF3N6O3S
CAS No.
SMILES

F[C@@H]1C[C@]2(COC3=NC4=C5C(OC[C@@]6(COCCCN64)[H])=C(Cl)[C@]([C@](C=CC(F)=C7S8)=C7C(C#N)=C8N)=C(F)C5=N3)CCCN2C1
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Room temperature in continental US; may vary elsewhere.
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KRAS inhibitor-27 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS inhibitor-273033690-83-1KRAS inhibitor27KRAS inhibitor 27RasERKp38 MAPKExtracellular signal regulated kinasesAsPC-1SW620HT-29Inhibitorinhibitorinhibit

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