2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. EGFR Akt ERK Apoptosis
  4. KU004

KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR and downstream Akt and Erk pathways and induces cell Apoptosis mainly via the extrinsic pathway. KU004 is a quinazoline derivative.

For research use only. We do not sell to patients.

KU004 Chemical Structure

KU004 Chemical Structure

CAS No. : 1260401-93-1

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KU004 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

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Description

KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR and downstream Akt and Erk pathways and induces cell Apoptosis mainly via the extrinsic pathway. KU004 is a quinazoline derivative[1][2].

Molecular Weight

548.98

Formula

C29H27ClFN4O2P
CAS No.
SMILES

ClC1=C(OCC2=CC(F)=CC=C2)C=CC(NC3=NC=NC4=CC=C(C#CCN5CCP(CC5)(C)=O)C=C43)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KU004 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KU0041260401-93-1KU 004KU-004EGFRAktERKApoptosisEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasesEGFR/HER2anticancer effectsbreast cancerG1 phase arrestErkapoptosisInhibitorinhibitorinhibit

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