2. PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. mTOR Endogenous Metabolite
  4. L-Leucine-d2

L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

For research use only. We do not sell to patients.

L-Leucine-d<sub>2</sub> Chemical Structure

L-Leucine-d2 Chemical Structure

CAS No. : 362049-59-0

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1 mg USD 90 In-stock
5 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of L-Leucine-d2:

L-Leucine-d2 Related Antibodies

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Description

L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Leucine-d2 Related Antibodies
Molecular Weight

133.19

Formula

C6H11D2NO2
CAS No.
Unlabeled CAS

61-90-5
Appearance

Solid

Color

White to off-white

SMILES

CC(C)C([2H])([2H])[C@H](N)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (93.85 mM; Need ultrasonic)

PBS (pH 7.2) : ≥ 1 mg/mL (7.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5081 mL 37.5404 mL 75.0807 mL
5 mM 1.5016 mL 7.5081 mL 15.0161 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) / H2O 1 mM 7.5081 mL 37.5404 mL 75.0807 mL 187.7018 mL
5 mM 1.5016 mL 7.5081 mL 15.0161 mL 37.5404 mL
H2O 10 mM 0.7508 mL 3.7540 mL 7.5081 mL 18.7702 mL
15 mM 0.5005 mL 2.5027 mL 5.0054 mL 12.5135 mL
20 mM 0.3754 mL 1.8770 mL 3.7540 mL 9.3851 mL
25 mM 0.3003 mL 1.5016 mL 3.0032 mL 7.5081 mL
30 mM 0.2503 mL 1.2513 mL 2.5027 mL 6.2567 mL
40 mM 0.1877 mL 0.9385 mL 1.8770 mL 4.6925 mL
50 mM 0.1502 mL 0.7508 mL 1.5016 mL 3.7540 mL
60 mM 0.1251 mL 0.6257 mL 1.2513 mL 3.1284 mL
80 mM 0.0939 mL 0.4693 mL 0.9385 mL 2.3463 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Leucine-d2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Leucine-d2362049-59-0mTOREndogenous MetaboliteMammalian target of RapamycinInhibitorinhibitorinhibit

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