L-Lysine-d₄ dihydrochloride

Name: L-Lysine-d 4 dihydrochloride
Brand: MedChemExpress
SKU: HY-W009762S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-W009762S2 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Lysine-d₄ (dihydrochloride) is the deuterium labeled L-Lysine dihydrochloride[1].

For research use only. We do not sell to patients.

L-Lysine-d<sub>4</sub> dihydrochloride Chemical Structure

L-Lysine-d₄ dihydrochloride Chemical Structure

CAS No. : 203633-22-1

Size	Price	Stock	Quantity
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Lysine-d₄ dihydrochloride:

H-Lys-OH.2HCl Get quote
L-Lysine-d4 Get quote
L-Lysine-d₄ hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Lysine-d₄ (dihydrochloride) is the deuterium labeled L-Lysine dihydrochloride[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

223.13

Formula

C₆H₁₂D₄Cl₂N₂O₂

CAS No.

203633-22-1

Unlabeled CAS

657-26-1

Appearance

Solid

Color

White to off-white

SMILES

NCC([2H])([2H])C([2H])([2H])C[C@H](N)C(O)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1120.42 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4817 mL	22.4085 mL	44.8169 mL
5 mM	0.8963 mL	4.4817 mL	8.9634 mL
10 mM	0.4482 mL	2.2408 mL	4.4817 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (245 KB) HNMR (257 KB) MS (109 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.4817 mL	22.4085 mL	44.8169 mL	112.0423 mL
	5 mM	0.8963 mL	4.4817 mL	8.9634 mL	22.4085 mL
	10 mM	0.4482 mL	2.2408 mL	4.4817 mL	11.2042 mL
	15 mM	0.2988 mL	1.4939 mL	2.9878 mL	7.4695 mL
	20 mM	0.2241 mL	1.1204 mL	2.2408 mL	5.6021 mL
	25 mM	0.1793 mL	0.8963 mL	1.7927 mL	4.4817 mL
	30 mM	0.1494 mL	0.7469 mL	1.4939 mL	3.7347 mL
	40 mM	0.1120 mL	0.5602 mL	1.1204 mL	2.8011 mL
	50 mM	0.0896 mL	0.4482 mL	0.8963 mL	2.2408 mL
	60 mM	0.0747 mL	0.3735 mL	0.7469 mL	1.8674 mL
	80 mM	0.0560 mL	0.2801 mL	0.5602 mL	1.4005 mL
	100 mM	0.0448 mL	0.2241 mL	0.4482 mL	1.1204 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.