2. Anti-infection
  3. HBV
  4. Lagociclovir valactate

Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent.

For research use only. We do not sell to patients.

Lagociclovir valactate Chemical Structure

Lagociclovir valactate Chemical Structure

CAS No. : 1001670-19-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Lagociclovir valactate Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent[1].

IC50 & Target

HBV[1]
In Vivo

Lagociclovir valactate (20 or 60 mg/kg; p.o.; daily for 10 weeks) shows anti-woodchuck hepatitis virus (WHV) activity in woodchucks[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Woodchucks with chronic WHV infection[1]
Dosage: 20 or 60 mg/kg
Administration: Oral, daily for 10 weeks
Result: Reduced WHV viremia effectively and maintained WHV DNA at a very low level.
Animal Model: Woodchucks[1]
Dosage: 10 or 40 mg/kg
Administration: Oral (Pharmacokinetic Analysis)
Result: Average pharmacokinetic parameters for Lagociclovir after oral administration of Lagociclovir valactate to healthy and chronically WHV infected woodchucks[1]
Pharmacokinetic parameter for Lagociclovir Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 10 mg/kg Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 40 mg/kg WHV-infected woodchucks (n = 14) receiving Lagociclovir valactate at 60 mg/kg
Cmax (μM) 0.54 ± 0.14 2.10 ± 1.5 3.50 ± 1.9
Tmax (h) 4.10 ± 1.0 3.30 ± 1.5 2.90 ± 1.1
AUC0-∞ (μM • h/liter) 5.15 ± 1.0 10.50 ± 4.2 20.1 ± 11.3
t1/2 (h) 5.44 ± 1.2 4.20 ± 1.6 4.7 ± 0.8
Molecular Weight

454.45

Formula

C19H27FN6O6
CAS No.
SMILES

O=C1C2=C(NC(N)=N1)N([C@](C[C@@H]3F)(C)O[C@@H]3COC([C@H](C)OC([C@@H](N)C(C)C)=O)=O)C=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Lagociclovir valactate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lagociclovir valactate1001670-19-4HBVHepatitis B virusLagociclovirWHVwoodchuck hepatitis virusInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Lagociclovir valactate
Cat. No.:
HY-107026
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.