2. Anti-infection
  3. HBV
  4. Lagociclovir valactate

Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent.

For research use only. We do not sell to patients.

Lagociclovir valactate Chemical Structure

Lagociclovir valactate Chemical Structure

CAS No. : 1001670-19-4

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Lagociclovir valactate Related Antibodies

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Description

Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent[1].

IC50 & Target

HBV[1]
In Vivo

Lagociclovir valactate (20 or 60 mg/kg; p.o.; daily for 10 weeks) shows anti-woodchuck hepatitis virus (WHV) activity in woodchucks[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Woodchucks with chronic WHV infection[1]
Dosage: 20 or 60 mg/kg
Administration: Oral, daily for 10 weeks
Result: Reduced WHV viremia effectively and maintained WHV DNA at a very low level.
Animal Model: Woodchucks[1]
Dosage: 10 or 40 mg/kg
Administration: Oral (Pharmacokinetic Analysis)
Result: Average pharmacokinetic parameters for Lagociclovir after oral administration of Lagociclovir valactate to healthy and chronically WHV infected woodchucks[1]
Pharmacokinetic parameter for Lagociclovir Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 10 mg/kg Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 40 mg/kg WHV-infected woodchucks (n = 14) receiving Lagociclovir valactate at 60 mg/kg
Cmax (μM) 0.54 ± 0.14 2.10 ± 1.5 3.50 ± 1.9
Tmax (h) 4.10 ± 1.0 3.30 ± 1.5 2.90 ± 1.1
AUC0-∞ (μM • h/liter) 5.15 ± 1.0 10.50 ± 4.2 20.1 ± 11.3
t1/2 (h) 5.44 ± 1.2 4.20 ± 1.6 4.7 ± 0.8
Molecular Weight

454.45

Formula

C19H27FN6O6
CAS No.
SMILES

O=C1C2=C(NC(N)=N1)N([C@](C[C@@H]3F)(C)O[C@@H]3COC([C@H](C)OC([C@@H](N)C(C)C)=O)=O)C=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lagociclovir valactate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lagociclovir valactate1001670-19-4HBVHepatitis B virusLagociclovirWHVwoodchuck hepatitis virusInhibitorinhibitorinhibit

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