2. Autophagy
  3. Autophagy p62
  4. LC3in-C42

LC3in-C42 is a cell-active LC3A/B and autophagy covalent inhibitor. LC3in-C42 selectively inhibits the binding of P62 to LC3A/B in vitro and at the cellular level like D5 and can function on a lower concentration.

For research use only. We do not sell to patients.

LC3in-C42 Chemical Structure

LC3in-C42 Chemical Structure

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LC3in-C42 Related Antibodies

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Description

LC3in-C42 is a cell-active LC3A/B and autophagy covalent inhibitor. LC3in-C42 selectively inhibits the binding of P62 to LC3A/B in vitro and at the cellular level like D5 and can function on a lower concentration[1].

In Vitro

LC3in-C42 is discovered utilizing the hybridization of advantageous fragments, whose potency (IC50 = 7.6 nM) has been greatly improved compared with that of DC-LC3inD5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LC3in-C42 Related Antibodies
Molecular Weight

394.29

Formula

C19H21Cl2N3O2
SMILES

O=C1/C(C(CC(C1)C2=C(C(Cl)=CC3=C2C=CN3)Cl)=O)=C/NCCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LC3in-C42 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC3in-C42Autophagyp62Sequestosome-1SQSTM1Inhibitorinhibitorinhibit

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