1. Metabolic Enzyme/Protease
  2. Dihydroorotate Dehydrogenase
  3. Leflunomide-d4

Leflunomide-d4 (HWA486-d4) is the deuterium labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent[1][2].

For research use only. We do not sell to patients.

Leflunomide-d<sub>4</sub> Chemical Structure

Leflunomide-d4 Chemical Structure

CAS No. : 1189987-23-2

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Based on 1 publication(s) in Google Scholar

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Description

Leflunomide-d4 (HWA486-d4) is the deuterium labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

274.23

Formula

C12H5D4F3N2O2

CAS No.
Unlabeled CAS
SMILES

C(NC1=C(C(=C(C(F)(F)F)C(=C1[2H])[2H])[2H])[2H])(=O)C2=C(C)ON=C2

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Leflunomide-d4
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HY-B0083S
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