2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride 

Cat. No.: HY-130682
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Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312). Lenalidomide-propargyl-C2-amido-Ph-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Chemical Structure

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Chemical Structure

CAS No. : 2748150-20-9

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Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312)[1]. Lenalidomide-propargyl-C2-amido-Ph-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

Cereblon

 

Molecular Weight

480.94

Formula

C25H25ClN4O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(CN1C3C(NC(CC3)=O)=O)C(C#CCCCNC(C4=CC=C(C=C4)N)=O)=CC=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenalidomide-propargyl-C2-amido-Ph-NH22748150-20-9E3 Ligase Ligand-Linker ConjugatesCRBNPROTACE3ubiquitinligaselinkerInhibitorinhibitorinhibit

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