2. Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease MAPK/ERK Pathway
  3. Calcium Channel Apoptosis Reactive Oxygen Species p38 MAPK NF-κB
  4. Lercanidipine hydrochloride (Standard)

Lercanidipine hydrochloride (Standard) 

Cat. No.: HY-B0612AR Purity: ≥98%
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Lercanidipine (hydrochloride) (Standard) is the analytical standard of Lercanidipine (hydrochloride). This product is intended for research and analytical applications. Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective and orally active dihydropyridine-calcium channel blocker with a pIC50 of 7.74 (converts from μM). Lercanidipine has long lasting antihypertensive action as well as reno- and neuro-protective effect. Lercanidipine also shows anti-oxidant, anti-inflammatory and anti-apoptotic properties. Lercanidipine can be used in cardiovascular and neurological research.

For research use only. We do not sell to patients.

Lercanidipine hydrochloride (Standard) Chemical Structure

Lercanidipine hydrochloride (Standard) Chemical Structure

CAS No. : 132866-11-6

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Description

Lercanidipine (hydrochloride) (Standard) is the analytical standard of Lercanidipine (hydrochloride). This product is intended for research and analytical applications. Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective and orally active dihydropyridine-calcium channel blocker with a pIC50 of 7.74 (converts from μM). Lercanidipine has long lasting antihypertensive action as well as reno- and neuro-protective effect. Lercanidipine also shows anti-oxidant, anti-inflammatory and anti-apoptotic properties. Lercanidipine can be used in cardiovascular and neurological research.

Molecular Weight

648.19

Formula

C36H42ClN3O6
CAS No.
SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OC(C)(C)CN(CCC(C3=CC=CC=C3)C4=CC=CC=C4)C.[H]Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Lercanidipine hydrochloride (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lercanidipine hydrochloride (Standard)132866-11-6Calcium ChannelApoptosisReactive Oxygen Speciesp38 MAPKNF-κBCa2+ channelsCa channelsNuclear factor-κBNuclear factor-kappaBanti-oxidantanti-inflammatoryanti-apoptoticanti-hypertensiveCalcium channel blockerrenoprotectiveneuroprotectivestrokeMCAo modelVSMCSHRInhibitorinhibitorinhibit

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