Leukotriene B4 ethanolamide  (Synonyms: LTB4 ethanolamide)

Leukotriene B4 ethanolamide (LTB4 ethanolamide) is an antagonist and a partial agonist for Leukotriene B4 (LTB4) receptor 1 (BLTR1). Leukotriene B4 ethanolamide ameliorates the tumor progression, which is only asscociated with inflammation^[1][2].

Leukotriene B4 ethanolamide suppresses the contractile action of LTB 4 in guinea-pig isolated lung parenchyma with K_b of 7.28 nM^[1].
Leukotriene B4 ethanolamide (1 μM) acts as a partial agonist for BLT receptor in cell PMN, induces PMN migration with pEC₅₀ of 7^[2].
Leukotriene B4 ethanolamide (1 μM) stimulates Ca²⁺ release in rat TRPV1-expressing CHO cells with pEC₅₀ of 7.28^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leukotriene B4 ethanolamide (100 nM/mouse/day for 5 days, s.c.) inhibits the tumor progression associated by inflammation in C57BL/6 mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

379.53

C₂₂H₃₇NO₄

877459-63-7

CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(NCCO)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. McHugh D, et al., Novel compounds that interact with both leukotriene B4 receptors and vanilloid TRPV1 receptors. J Pharmacol Exp Ther. 2006 Feb;316(2):955-65.  [Content Brief]

  [2]. Bachi AL, et al., Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. Mol Cancer Res. 2009 Sep;7(9):1417-24.  [Content Brief]