Longestin (Synonyms: KS-505a)

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Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent.

For research use only. We do not sell to patients.

Longestin Chemical Structure

CAS No. : 131774-53-3

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Description	Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent^[1]^[2].
Molecular Weight	1093.34
Formula	C₆₁H₈₈O₁₇
CAS No.	131774-53-3
SMILES	OC[C@@]12[C@]3([H])[C@]([C@@]4([H])[C@](CC3)(OC5=CC=C(C(O)(OC6=O)CCC(OC)=O)C6=C5C4)CO)(CC[C@@]1([H])[C@]7([C@]([C@@]8([C@@]([C@]9([C@]([C@@]%10([C@@]([C@](C)([C@H](C[C@H]%10C)O[C@H]%11[C@@H]([C@H]([C@@H]([C@H](O%11)C(O)=O)O)O)OC)C(O)=O)([H])CC9)C)([H])C[C@H]8C)C)([H])CC7)C)([H])CC2)C)C
Structure Classification	Antibiotics Other Antibiotics
Initial Source	Microorganisms Streptomyces argenteolus A-2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Ozaki T, et al. Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit. Angew Chem Int Ed Engl. 2018 May 28;57(22):6629-6632. [Content Brief] [2]. Hayashi Y, et al. Cloning of the gene cluster responsible for biosynthesis of KS-505a (longestin), a unique tetraterpenoid. Biosci Biotechnol Biochem. 2007 Dec;71(12):3072-81. [Content Brief]

Longestin Related Classifications

Neurological Disease Infection

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Longestin131774-53-3KS-505aPhosphodiesterase (PDE)ParasitephosphodiesteraseantitrypanosomalStreptomyces argenteolusanti-amnesia agentInhibitorinhibitorinhibit

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