1. GPCR/G Protein
  2. Adenosine Receptor
  3. Lu AA47070

Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.

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Lu AA47070 Chemical Structure

Lu AA47070 Chemical Structure

CAS No. : 913842-25-8

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Description

Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].

In Vivo

Lu AA47070 (3.75, 7.5, 15, 30 mg/kg; i.p.) reverseS the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP)[2].
Pharmacokinetic Parameters of Lu AA47070 in Sprague-Dawley rats[1].

Compd dose (mg/kg) AUC(ng*h/L) Tmax (h) Cmax (ng/mL) F (%)
32 1.5 2.9±0.7 0.5±0.1 869±68 55±13
32 15 35±3.0 0.4±0.2 6413±281 66±6
Sprague-Dawley rats, 1.5, 15 mg/kg po[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats[2]
Dosage: 3.75, 7.5, 15, 30 mg/kg
Administration: I.p.
Result: Reversed the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP).
Molecular Weight

463.39

Formula

C17H20F2N3O6PS

CAS No.
SMILES

O=P(O)(O)OCN1C=CS/C1=N\C(C2=CC(F)=C(NC(CC(C)(C)C)=O)C(F)=C2)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Lu AA47070 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Lu AA47070
Cat. No.:
HY-14408
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