2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Luffariellolide

Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC50=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED50=50 μg/ear).

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Luffariellolide Chemical Structure

Luffariellolide Chemical Structure

CAS No. : 111149-87-2

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Based on 1 publication(s) in Google Scholar

Luffariellolide Related Antibodies

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Description

Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC50=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED50=50 μg/ear)[1].

Cellular Effect
Cell Line Type Value Description References
L5178Y ED50
3.3 μg/mL
Compound: 6
Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
[PMID: 15568767]
MDA-MB-231 IC50
4.5 μM
Compound: 11
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 23944963]
T47D IC50
3.6 μM
Compound: 11
Inhibition of hypoxia-induced HIF-1 activation in human T47D cells by luciferase reporter gene assay
Inhibition of hypoxia-induced HIF-1 activation in human T47D cells by luciferase reporter gene assay
[PMID: 23944963]
T47D IC50
5.1 μM
Compound: 11
Antiproliferative activity against human T47D cells after 48 hrs by SRB assay
Antiproliferative activity against human T47D cells after 48 hrs by SRB assay
[PMID: 23944963]
Molecular Weight

386.57

Formula

C25H38O3
CAS No.
SMILES

CC1(CCCC(C)=C1CC/C(C)=C/CC/C(C)=C/CCC2=CC(OC2O)=O)C
Structure Classification
Initial Source

Palauan sponge
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Luffariellolide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luffariellolide111149-87-2Phospholipasehuman synovial fluid phospholipase A2HSF-PLA2ear edemaInhibitorinhibitorinhibit

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HY-118725
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