LY-503430

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LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease.

For research use only. We do not sell to patients.

LY-503430 Chemical Structure

CAS No. : 625820-83-9

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References
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Description

LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease^[1].

In Vitro

The submicromolar concentrations of LY-503430 (0.03-10 μM) selectively enhances glutamate-induced calcium influx into human embryonic kidney 293 cells transfected with human GLUA1, GLUA2, GLUA3, or GLUA4 AMPA receptors. LY-503430 also potentiates AMPA-mediated responses in native cortical, hippocampal, and substantia nigra neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LY503430 (0.5 mg/kg; s.c; once a day; for 11 days) has functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57Bl6J mice (20-25 g) injected with MPTP (HY-15608)^[1]
Dosage:	0.5 mg/kg
Administration:	s.c; once a day; for 11 days
Result:	Prevention of MPTP-induced neurotoxicity in mice.

Molecular Weight

392.49

Formula

C₂₀H₂₅FN₂O₃S

CAS No.

625820-83-9

SMILES

O=C(C1=CC=C(C2=CC=C([C@](C)(F)CNS(=O)(C(C)C)=O)C=C2)C=C1)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tracey K Murray, et al. LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2003 Aug;306(2):752-62. [Content Brief]

LY-503430 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY-503430625820-83-9LY503430LY 503430iGluRIonotropic glutamate receptorsAMPA receptor PAMParkinson's diseaseorally activeInhibitorinhibitorinhibit

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