2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs NAMPT
  4. LYP-8

LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro(Sturcture Note:(Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801)；Pink: Nampt inhibitor Nampt-IN-11 (HY-158689)).

For research use only. We do not sell to patients.

LYP-8 Chemical Structure

LYP-8 Chemical Structure

Size Price Stock Quantity
5 mg Get quote 10 - 12 weeks 10 - 12 weeks 9 - 11 weeks
10 mg Get quote 10 - 12 weeks 10 - 12 weeks 9 - 11 weeks
25 mg Get quote 10 - 12 weeks 10 - 12 weeks 9 - 11 weeks
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro(Sturcture Note:(Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801)；Pink: Nampt inhibitor Nampt-IN-11 (HY-158689))[1].

Molecular Weight

1051.30

Formula

C56H74N8O10S
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C4=CC=C(C=C4)C(N5CCC(CC5)CCCCNC(/C=C/C6=CN=CC=C6)=O)=O)=O)=O)=O)O)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LYP-8 Related Classifications

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Keywords:

LYP-8LYP8LYP 8PROTACsNAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorSKOV-3MNK-45CT-26Inhibitorinhibitorinhibit

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HY-162537
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