m-PEG10-CH2COOH

Cat. No.: HY-133285 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

m-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG10-CH2COOH Chemical Structure

CAS No. : 908258-58-2

Size	Price	Stock	Quantity
50 mg	USD 33	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 52	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 87	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 143	Get quote	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Biological Activity
Purity & Documentation
References
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Description

m-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

530.60

Formula

C₂₃H₄₆O₁₃

CAS No.

908258-58-2

Appearance

Liquid (Density: 1.122 g/cm³)

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (188.47 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8847 mL	9.4233 mL	18.8466 mL
5 mM	0.3769 mL	1.8847 mL	3.7693 mL
10 mM	0.1885 mL	0.9423 mL	1.8847 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (264 KB) SDS (392 KB)

COA (237 KB) HNMR (137 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.8847 mL	9.4233 mL	18.8466 mL	47.1165 mL
	5 mM	0.3769 mL	1.8847 mL	3.7693 mL	9.4233 mL
	10 mM	0.1885 mL	0.9423 mL	1.8847 mL	4.7116 mL
	15 mM	0.1256 mL	0.6282 mL	1.2564 mL	3.1411 mL
	20 mM	0.0942 mL	0.4712 mL	0.9423 mL	2.3558 mL
	25 mM	0.0754 mL	0.3769 mL	0.7539 mL	1.8847 mL
	30 mM	0.0628 mL	0.3141 mL	0.6282 mL	1.5705 mL
	40 mM	0.0471 mL	0.2356 mL	0.4712 mL	1.1779 mL
	50 mM	0.0377 mL	0.1885 mL	0.3769 mL	0.9423 mL
	60 mM	0.0314 mL	0.1571 mL	0.3141 mL	0.7853 mL
	80 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.5890 mL
	100 mM	0.0188 mL	0.0942 mL	0.1885 mL	0.4712 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

m-PEG10-CH2COOH Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG10-CH2COOH908258-58-2PROTAC LinkersInhibitorinhibitorinhibit

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