2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. M62812 free base

M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis.

For research use only. We do not sell to patients.

M62812 free base Chemical Structure

M62812 free base Chemical Structure

CAS No. : 613262-61-6

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M62812 free base Related Antibodies

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Description

M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
7 μM
Compound: 23
Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay
Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay
[PMID: 18828583]
In Vitro

M62812 (0-10 μg/ml) suppresses LPS-induced upregulation of inflammatory cytokines, adhesion molecules and procoagulant activity in human vascular endothelial cells and peripheral mononuclear cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M62812 free base Related Antibodies
In Vivo

M62812 (i.v.; 10-20 mg/kg; single) protects mice from lethality and reduced inflammatory and coagulatory parameters in a murine d-galactosamine-sensitized endotoxin shock model[1].
M62812 (20 mg/kg/day) prevents mice from lethality in a murine cecal ligation and puncture model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: D-galactosamine-sensitized endotoxin shock mouse model[1]
Dosage: 10-20 mg/kg
Administration: Single intravenous administration
Result: Suppressed LPS-induced leukocyte and endothelial cell activation in vivo.
Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.
Animal Model: A cecal ligation and puncture mouse model[1]
Dosage: 20 mg/kg
Administration: Intravenous administration; Everyday
Result: Reduced mortality in a murine cecal ligation and puncture model.
Molecular Weight

257.31

Formula

C13H11N3OS
CAS No.
SMILES

NC1=NSC2=C1C=CC(OC3=CC=CC=C3N)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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M62812 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M62812613262-61-6M 62812M-62812Toll-like Receptor (TLR)toll-like receptors (TLRs)TLR4LipopolysaccharidesepsisInhibitorinhibitorinhibit

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