2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Ser/Thr Protease Potassium Channel
  4. MASP-2-IN-1

MASP-2-IN-1 (Compound 77) is the inhibitor for mannan-binding lectin-associated serine protease (MASP), that inhibits MASP2 and MASP3 with IC50 of 11.4 nM and 13.2 µM. MASP-2-IN-1 exhibits a weak inhibitory activity against hERG with an IC50 of 175 µM. MASP-2-IN-1 reveals a poor stability in mouse plasma with a half-life of 4.4 hours.

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MASP-2-IN-1 Chemical Structure

MASP-2-IN-1 Chemical Structure

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MASP-2-IN-1 Related Antibodies

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Description

MASP-2-IN-1 (Compound 77) is the inhibitor for mannan-binding lectin-associated serine protease (MASP), that inhibits MASP2 and MASP3 with IC50 of 11.4 nM and 13.2 µM. MASP-2-IN-1 exhibits a weak inhibitory activity against hERG with an IC50 of 175 µM. MASP-2-IN-1 reveals a poor stability in mouse plasma with a half-life of 4.4 hours[1].

Molecular Weight

463.51

Formula

C22H21N7O3S
SMILES

NC1=NC(C2=CC=C(C=C2)CNC(CC3=NC=C(C=N3)NS(=O)(C4=CC=CC=C4)=O)=O)=CN1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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MASP-2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MASP-2-IN-1Ser/Thr ProteasePotassium ChannelSerine proteasesSerine endopeptidasesThreonine proteasesKcsAInhibitorinhibitorinhibit

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