MAT2A-IN-23 

MAT2A-IN-23 (compound 39) is a MAT2A inhibitor, with an IC₅₀ of 4 nM. MAT2A-IN-23 inhibits SAM in the HCT-116 (MTAP^−/−) and in the HCT-116 WT cell line with IC₅₀s of 3 and 2 nM, respectively. MAT2A-IN-23 inhibits SDMA in the HCT-116 (MTAP^−/−) and in the HCT-116 WT cell line with IC₅₀s of 2 and >3000 nM, respectively. MAT2A-IN-23 inhibits HCT-116 (MTAP^−/−) cell proliferation with with an IC₅₀ of 47 nM^[1].

344.37

C₁₉H₁₄D₃F₂N₃O

2925324-58-7

O=C1[C@]2(C3=CC(C(F)(C)F)=CC=C3C(NC([2H])([2H])[2H])=N1)C4=CC=CN=C4CC2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang S, et al. Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models. J Med Chem. 2025 Feb 13;68(3):3480-3494.  [Content Brief]