MBX-1066

Cat. No.: HY-129318: FAQs
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MBX 1066 is a potent antibacterial agent. MBX 1066 shows inhibition for Mycobacterium tuberculosis. MBX 1066 shows antibacterial activity in mice.

For research use only. We do not sell to patients.

MBX-1066 Chemical Structure

CAS No. : 868971-24-8

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Biological Activity
Purity & Documentation
References
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Description

MBX 1066 is a potent antibacterial agent. MBX 1066 shows inhibition for Mycobacterium tuberculosis. MBX 1066 shows antibacterial activity in mice^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	CC₅₀	3 μg/mL Compound: MBX-1066, NSC-317881	Cytotoxicity against human HeLa cells after 3 days by MTS assay in presence of 10% fetal calf serum Cytotoxicity against human HeLa cells after 3 days by MTS assay in presence of 10% fetal calf serum	[PMID: 19635954]
HeLa	CC₅₀	32.5 μg/mL Compound: 1066	Cytotoxicity against human HeLa cells by MTS assay Cytotoxicity against human HeLa cells by MTS assay	[PMID: 24969013]
HeLa	CC₅₀	33 μg/mL Compound: MBX-1066	Cytotoxicity against HeLa cells after 3 days by MTS assay Cytotoxicity against HeLa cells after 3 days by MTS assay	[PMID: 20625154]

In Vitro

MBX 1066 shows cytotoxicity for HeLa cells with a CC₅₀ value of 33 µg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MBX 1066 (1, 10 mg/kg; i.v.; single dose, one hour post infection) shows antibacterial activity and increases the mice survival^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ICR/Swiss Webster mice (Staphylococcus aureus strain NRS384) ^[1]
Dosage:	1, 10 mg/kg
Administration:	I.v.; single dose, one hour post infection
Result:	Increased the survival in a dose-dependent maner.

Molecular Weight

444.53

Formula

C₂₈H₂₄N₆

CAS No.

868971-24-8

SMILES

C1(C2=CC=C(C=C2)C3=CC4=C(C=C(C=C4)C5=NCCN5)N3)=CC6=C(C=C(C=C6)C7=NCCN7)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Panchal RG, et al. Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis. J Antibiot (Tokyo). 2013 Jan;66(1):47-9. [Content Brief]

MBX-1066 Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MBX-1066868971-24-8MBX1066MBX 1066BacterialHeLa cellsStaphylococcus aureusMycobacterium tuberculosisantibacterialcytotoxicityInhibitorinhibitorinhibit

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