2. Apoptosis Immunology/Inflammation Cell Cycle/DNA Damage Autophagy
  3. FKBP
  4. MC-25B

MC-25B is a specific FKBP12 PROTAC degrader. MC-25B degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a DCAF16-dependent mechanism. (Pink: FKBP12 ligand (HY-170988); Blue: E3 ligase ligand HY-170986); Black: linker (HY-128844); FKBP12 ligand+ linker (HY-170987)).

For research use only. We do not sell to patients.

MC-25B Chemical Structure

MC-25B Chemical Structure

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MC-25B Related Antibodies

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Description

MC-25B is a specific FKBP12 PROTAC degrader. MC-25B degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a DCAF16-dependent mechanism. (Pink: FKBP12 ligand (HY-170988); Blue: E3 ligase ligand HY-170986); Black: linker (HY-128844); FKBP12 ligand+ linker (HY-170987))[1].

Molecular Weight

1230.92

Formula

C65H92ClN7O14
SMILES

O=C(CN1CCN(C2=CC=CC(C(N3CCC(N(C4CC4)C(CCl)=O)CC3)=O)=C2)CC1)NCCCOCCOCCOCCCNC(COC5=CC=CC([C@H](OC([C@@H]6CCCCN6C(C(C(C)(C)CC)=O)=O)=O)CCC7=CC(OC)=C(OC)C=C7)=C5)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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MC-25B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-25BFKBPFK506-binding proteintargeted protein degradationcellular proteostasisHEK293T cellsMDA-MB-231 cellsInhibitorinhibitorinhibit

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