MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH

Cat. No.: HY-131990A: FAQs
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MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH Chemical Structure

CAS No. : 1802520-40-6

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Description	MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH Related Antibodies
Molecular Weight	616.62
Formula	C₂₈H₃₆N₆O₁₀
CAS No.	1802520-40-6
Appearance	Solid
Color	White to off-white
SMILES	OC(COCNC(CNC([C@H](NC(CNC(CNC(CCCCCN1C(C=CC1=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Masuda, Takeshi, et al. Conjugué anticorps-médicament. WO2014057687A1.

MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH1802520-40-6ADC LinkerAntibody-drug conjugates linkerADCcleavablelinkerInhibitorinhibitorinhibit

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MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH

MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH Related Antibodies

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