2. Academic Validation
  3. Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis

Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis

  • Bioorg Med Chem Lett. 1999 Feb 8;9(3):313-8. doi: 10.1016/s0960-894x(98)00749-5.
M H Chen 1,  M G Steiner,  S E de Laszlo,  A A Patchett,  M S Anderson,  S A Hyland,  H R Onishi,  L L Silver,  C R Raetz
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
PMID: 10091675 DOI: 10.1016/s0960-894x(98)00749-5
Abstract

A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, the Enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L-161,240 showed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1-3 microg/mL against wild-type E. coli.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-114737
    UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc Deacetylase Inhibitor