2. Academic Validation
  3. Isolation and identification of dihydroartemisinic acid from artemisia annua and its possible role in the biosynthesis of artemisinin

Isolation and identification of dihydroartemisinic acid from artemisia annua and its possible role in the biosynthesis of artemisinin

  • J Nat Prod. 1999 Mar;62(3):430-3. doi: 10.1021/np980370p.
TE Wallaart 1,  van Uden W,  HG Lubberink,  HJ Woerdenbag,  N Pras,  WJ Quax
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies, University of Groningen, A. Deusinglaan 1, NL-9713 AV Groningen, The Netherlands.
PMID: 10096851 DOI: 10.1021/np980370p
Abstract

Dihydroartemisinic acid (2) was isolated as a natural product from Artemisia annua in a 66% yield, and its structure was confirmed by 1H and 13C NMR spectroscopy. Compound 2 could be chemically converted to artemisinin (4) under conditions that may also be present in the living plant. The results suggest that the conversion of 2 into 4 in the living plant might be a nonenzymatic conversion.

Figures
Products