1. Academic Validation
  2. Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats

Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats

  • Gen Pharmacol. 1999 Mar;32(3):299-305. doi: 10.1016/s0306-3623(98)00180-3.
M Nishikawa 1 Y Kubo H Kido T Nakayama N Nakamura
Affiliations

Affiliation

  • 1 Research Division, The Green Cross Corporation, Osaka, Japan. ac43451@yoshitomi.co.jp
Abstract

We investigated the protective effect of chronic treatment with AE0047, a dihydropyridine-type Calcium Channel blocker, on vascular endothelial abnormalities in stroke-prone spontaneously hypertensive rats (SHRSP). Ten-week repeated antihypertensive treatment with AE0047 inhibited blood pressure elevation and improved endothelium-dependent relaxation in response to acetylcholine in aorta isolated from SHRSP. Furthermore, the abnormal production of prostaglandin I2 and thromboxane A2 in the aorta was normalized to a level equivalent to that in Wistar-Kyoto rats. These results suggest that chronic treatment with AE0047 exerts protective effects against endothelial abnormalities associated with the development of hypertension.

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