2. Academic Validation
  3. Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs

Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs

  • Bioorg Med Chem Lett. 1999 Sep 20;9(18):2731-6. doi: 10.1016/s0960-894x(99)00472-2.
J S Zhang 1,  J Ding,  Q M Tang,  M Li,  M Zhao,  L J Lu,  L J Chen,  S T Yuan
Affiliations

Affiliation

  • 1 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China. jszhang@mail.shcnc.ac.cn
PMID: 10509925 DOI: 10.1016/s0960-894x(99)00472-2
Abstract

A novel diterpenequinone named salvicine (4), structurally modified derivative of a natural product, and a series of the novel analogs have been prepared. Most of the analogs were found to be potently active against tumor cell lines in vitro. Further study on 4 in vivo demonstrated that it possessed a significant antineoplastic activity against murine S-180 Sarcoma and Lewis lung Cancer, and human lung adenocarcinoma xenografts A-549 and LAX-83. The preclinical studies of 4 are now under way.

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