2. Academic Validation
  3. Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1

Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1

  • Science. 2000 Mar 24;287(5461):2274-7. doi: 10.1126/science.287.5461.2274.
S Faure 1,  L Meyer,  D Costagliola,  C Vaneensberghe,  E Genin,  B Autran,  J F Delfraissy,  D H McDermott,  P M Murphy,  P Debré,  I Théodorou,  C Combadière
Affiliations

Affiliation

  • 1 Laboratoire d'Immunologie Cellulaire et Tissulaire, Centre National de la Recherche Scientifique UMR 7627, Hôpital Pitié-Salpétrière, Paris, France.
PMID: 10731151 DOI: 10.1126/science.287.5461.2274
Abstract

Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor and leukocyte chemotactic/adhesion receptor for the chemokine fractalkine. HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two Amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes. Functional CX3CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX3CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS.

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