2. Academic Validation
  3. An efficient method for the synthesis of sulbactam pivoxil

An efficient method for the synthesis of sulbactam pivoxil

  • Farmaco. 2000 Feb;55(2):134-5. doi: 10.1016/s0014-827x(00)00005-7.
L S Changov 1,  B K Vassileva,  M N Confino,  N N Agapova
Affiliations

Affiliation

  • 1 University of Chemical Technology and Metallurgy, Sofia, Bulgaria. lschangov@hotmail.com
PMID: 10782385 DOI: 10.1016/s0014-827x(00)00005-7
Abstract

Sulbactam pivoxil, a prodrug of the Beta-lactamase Inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by filtration. Dimethyl sulfoxide was found to be the solvent of choice among several aprotic organic Solvents.

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