2. Academic Validation
  3. New 7,20:14,20-diepoxy ent-kauranoids from Isodon xerophilus

New 7,20:14,20-diepoxy ent-kauranoids from Isodon xerophilus

  • J Nat Prod. 2000 May;63(5):599-601. doi: 10.1021/np9903705.
A J Hou 1,  M L Li,  B Jiang,  Z W Lin,  S Y Ji,  Y P Zhou,  H D Sun
Affiliations

Affiliation

  • 1 Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Yunnan, People's Republic of China.
PMID: 10843567 DOI: 10.1021/np9903705
Abstract

Three new 7,20:14,20-diepoxy-ent-kaurane Diterpenoids, xerophilusins A-C (1-3), together with a known one, macrocalin B (4), were isolated from the leaves of Isodon xerophilus. Their structures were elucidated on the basis of their spectral properties and X-ray crystallographic analysis. Compounds 1, 2, and 4 showed significant cytotoxic activity against K562, HL-60, and MKN-28 cells.

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