2. Academic Validation
  3. Cytotoxic lavandulyl flavanones from Sophora flavescens

Cytotoxic lavandulyl flavanones from Sophora flavescens

  • J Nat Prod. 2000 May;63(5):680-1. doi: 10.1021/np990567x.
T H Kang 1,  S J Jeong,  W G Ko,  N Y Kim,  B H Lee,  M Inagaki,  T Miyamoto,  R Higuchi,  Y C Kim
Affiliations

Affiliation

  • 1 College of Pharmacy, Wonkwang University, Iksan, 570-749, Korea.
PMID: 10843587 DOI: 10.1021/np990567x
Abstract

Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (-)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.

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