Functional glycerol kinase activity and the possibility of a major role for glyceroneogenesis in mammalian skeletal muscle

According to textbook descriptions of glycerol metabolism, liver and kidney are the only tissues that express significant glycerol kinase activity. Thus esterification of fatty acids to triglycerides in peripheral tissues such as skeletal muscle and adipose tissue is presumed to be dependent on the synthesis of glycerol-3-phosphate from glucose. This report describes exciting new data indicating that, although low, the glycerol kinase activity of skeletal muscle is functional. Interestingly, the results also suggest that neither glycerol nor glucose is the major substrate for the synthesis of muscle triglyceride glycerol. Rather, glyceroneogenesis, the synthesis of glycerol-3-phosphate from lactate, may play an as yet under-appreciated, but quantitatively important, role.