2. Academic Validation
  3. Bioactive compounds from Psorothamnus junceus

Bioactive compounds from Psorothamnus junceus

  • J Nat Prod. 2000 Sep;63(9):1244-8. doi: 10.1021/np990171l.
H Zhang 1,  X Li,  C L Ashendel,  C J Chang
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA.
PMID: 11000028 DOI: 10.1021/np990171l
Abstract

During a search for bioactive compounds from Psorothamnus junceus, four heterocyclic compounds, psorothamnone A (1), psorothamnone B (2), dalrubone (3), and emorydone (4) were isolated from the ethanol extract of the stem bark. Psorothamnones A (1) and B (2) demonstrated inhibitory activity against protein kinase C (PKC), a key Enzyme involved in the signal transduction of cell proliferation and differentiation. Dalrubone (3) and emorydone (4) showed cytotoxicity against several human tumor cell lines.

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