2. Academic Validation
  3. Thrombin signalling and protease-activated receptors

Thrombin signalling and protease-activated receptors

  • Nature. 2000 Sep 14;407(6801):258-64. doi: 10.1038/35025229.
S R Coughlin 1
Affiliations

Affiliation

  • 1 Cardiovascular Research Institute and Department of Medicine, University of California at San Francisco, 94143-0130, USA. coughlin@cvrimail.ucsf.edu
PMID: 11001069 DOI: 10.1038/35025229
Abstract

How does the coagulation protease Thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.

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