2. Academic Validation
  3. Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins

Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins

  • FEBS Lett. 2001 Feb 23;491(1-2):104-8. doi: 10.1016/s0014-5793(01)02144-5.
S Schlosser 1,  F Gansauge,  M Ramadani,  H G Beger,  S Gansauge
Affiliations

Affiliation

  • 1 Division of Molecular Oncology, Department of General Surgery, University of Ulm, Steinhövelstrasse 9, 89075, Ulm, Germany.
PMID: 11226429 DOI: 10.1016/s0014-5793(01)02144-5
Abstract

Caspase-1 (interleukin-1beta-converting Enzyme) is reported to play an important role in the regulation of Apoptosis. We investigated the inhibition of Caspase-1 by the cell permeable Caspase-1 inhibitor Ac-AAVALLPAVLLALLAP-YVAD.CHO in pancreatic carcinoma cells. Inhibition of Caspase-1 induced a non-apoptotic/"necrotic-like" cell death in AsPC-1, BxPC-3, MiaPaCa-2 and Panc-1 cells. Expression levels of Bcl-2 and Bax were up-regulated in Caspase-1 inhibitor-treated cells while that of bcl-x(L) remained unaltered. Our observations support our previous findings that Caspase-1 is potentially involved in anti-apoptotic processes in pancreatic carcinoma.

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