2. Academic Validation
  3. Cytotoxic constituents of the fruits of Cananga odorata

Cytotoxic constituents of the fruits of Cananga odorata

  • J Nat Prod. 2001 May;64(5):616-9. doi: 10.1021/np0005208.
T J Hsieh 1,  F R Chang,  Y C Chia,  C Y Chen,  H F Chiu,  Y C Wu
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
PMID: 11374955 DOI: 10.1021/np0005208
Abstract

A new guaipyridine sesquiterpene alkaloid, cananodine (1), and two new eudesmane Sesquiterpenes, cryptomeridiol 11-alpha-L-rhamnoside (2) and gamma-eudesmol 11-alpha-L-rhamnoside (3), along with gamma-eudesmol (4), were isolated from the fruits of Cananga odorata. The structures of compounds 1-3 were established on the basis of NMR and MS methods. In addition, compounds 1-4 and four previously reported Alkaloids, cleistopholine (5), N-trans-feruloyltyramine (6), (+)-ushinsunine-beta-N-oxide (7), and lyscamine (8), were evaluated for cytotoxicity against two human hepatocarcinoma cell lines.

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