2. Academic Validation
  3. Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase

Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase

  • Bioorg Med Chem Lett. 2001 Dec 3;11(23):3085-8. doi: 10.1016/s0960-894x(01)00635-7.
C Chamorro 1,  E Lobatón,  M C Bonache,  E De Clercq,  J Balzarini,  S Velázquez,  A San-Félix,  M J Camarasa
Affiliations

Affiliation

  • 1 Instituto de Química Médica (C.S.I.C.), Juan de la Cierva 3, 28006-Madrid, Spain.
PMID: 11714616 DOI: 10.1016/s0960-894x(01)00635-7
Abstract

N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.

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