1. Academic Validation
  2. Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production

Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production

  • J Nat Prod. 2002 Jan;65(1):89-91. doi: 10.1021/np010428r.
Hui Zi Jin 1 Bang Yeon Hwang Hang Sub Kim Jeong Hyung Lee Young Ho Kim Jung Joon Lee
Affiliations

Affiliation

  • 1 Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
Abstract

Two new sesquiterpene esters, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran (1) and 1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-kappaB activation and nitric oxide production. Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-kappaB activation and nitric oxide production.

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