2. Academic Validation
  3. 5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity

5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity

  • Bioorg Med Chem Lett. 2002 Feb 11;12(3):275-8. doi: 10.1016/s0960-894x(01)00735-1.
Rakesh Kumar 1
Affiliations

Affiliation

  • 1 Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Alberta, Edmonton, Canada T6G 2H7. rakesh.kumar@ualberta.ca
PMID: 11814776 DOI: 10.1016/s0960-894x(01)00735-1
Abstract

Synthesis, Antiviral, and cytotoxic activities of 5-bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine (4,5) and -thymidine (6,7) are reported. Compounds 4 and 5 exhibited a broad spectrum of antiherpes activity against (HSV-1, HSV-2, HCMV, and VZV).

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