2. Academic Validation
  3. New indene-derivatives with anti-proliferative properties

New indene-derivatives with anti-proliferative properties

  • Bioorg Med Chem Lett. 2002 Feb 25;12(4):709-13. doi: 10.1016/s0960-894x(01)00839-3.
Ioanna-Maria Karaguni 1,  Karl-Heinz Glüsenkamp,  Anette Langerak,  Christoph Geisen,  Volker Ullrich,  Günther Winde,  Tarik Möröy,  Oliver Müller
Affiliations

Affiliation

  • 1 Max-Planck-Institut fur Molekulare Physiologie, Dortmund, Germany.
PMID: 11844707 DOI: 10.1016/s0960-894x(01)00839-3
Abstract

Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.

Figures