2. Academic Validation
  3. Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds

Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds

  • J Nat Prod. 2002 Feb;65(2):206-9. doi: 10.1021/np010073b.
Cui-Ying Ma 1,  Wing Keung Liu,  Chun-Tao Che
Affiliations

Affiliation

  • 1 Department of Chemistry, Hong Kong University of Science and Technology, Hong Kong.
PMID: 11858758 DOI: 10.1021/np010073b
Abstract

Four lignanamides, a tyramine derivative, and 10 Other nonalkaloidal components were isolated from the seeds of Hyoscyamus niger. Among them, hyoscyamide (1), 1,24-tetracosanediol diferulate (6), and 1-O-(9Z,12Z-octadecadienoyl)-3-O-nonadecanoyl glycerol (7) are new structures. The Other compounds were identified as grossamide, cannabisin D, cannabisin G, N-trans-feruloyl tyramine, 1-O-octadecanoyl glycerol, 1-O-(9Z,12Z-octadecadienoyl) glycerol, 1-O-(9Z,12Z-octadecadienoyl)-2-O-(9Z,12Z-octadecadienoyl) glycerol, 1-O-(9Z,12Z-octadecadienoyl)-3-O-(9Z-octadecenoyl) glycerol, rutin, vanillic acid, beta-sitosterol, and daucosterol. Grossamide, and cannabisins D and G exhibited moderate cytotoxicity in cultured LNCaP human prostate Cancer cells.

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