2. Academic Validation
  3. Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages

Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages

  • J Nat Prod. 2002 Mar;65(3):379-81. doi: 10.1021/np0101651.
Shiow-Hwa Day 1,  Yi-Chen Lin,  Mei-Lin Tsai,  Lo-Ti Tsao,  Horng-Huey Ko,  Mei-Ing Chung,  Jeng-Chang Lee,  Jih-Pyang Wang,  Shen-Jeu Won,  Chun-Nan Lin
Affiliations

Affiliation

  • 1 School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
PMID: 11908984 DOI: 10.1021/np0101651
Abstract

A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of Cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-alpha (TNF-alpha) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).

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