2. Academic Validation
  3. Cephalocyclidin A, a novel pentacyclic alkaloid from Cephalotaxus harringtonia var. nana

Cephalocyclidin A, a novel pentacyclic alkaloid from Cephalotaxus harringtonia var. nana

  • J Org Chem. 2002 Apr 5;67(7):2283-6. doi: 10.1021/jo016327f.
Jun'ichi Kobayashi 1,  Miwa Yoshinaga,  Naotoshi Yoshida,  Motoo Shiro,  Hiroshi Morita
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
PMID: 11925242 DOI: 10.1021/jo016327f
Abstract

A novel alkaloid with an unprecedented fused-pentacyclic skeleton and six-consecutive asymmetric centers, cephalocyclidin A (1), has been isolated from the fruits of Cephalotaxus harringtonia var. nana, and the structure was elucidated on the basis of spectroscopic data. The relative and absolute stereochemistry of 1 was determined by a combination of NOESY correlations, X-ray crystallographic data, and the exciton chirality method.

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