2. Academic Validation
  3. Cytotoxic diarylheptanoids from the roots of Juglans mandshurica

Cytotoxic diarylheptanoids from the roots of Juglans mandshurica

  • J Nat Prod. 2002 Nov;65(11):1707-8. doi: 10.1021/np0201063.
Kyung-Seon Lee 1,  Gao Li,  Sung Hwan Kim,  Chong-Soon Lee,  Mi-Hee Woo,  Seung-Ho Lee,  Yurng-Dong Jhang,  Jong-Keun Son
Affiliations

Affiliation

  • 1 College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea.
PMID: 12444709 DOI: 10.1021/np0201063
Abstract

A new (2) and three known diarylheptanoids (1, 3, and 4), along with one known sesquiterpenoid (5), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. Four of these compounds (2-5) exhibited moderate cytotoxicities against human colon carcinoma and human lung carcinoma cell lines with IC(50)'s ranging from 2 to 25 microg/mL.

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